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Anti-GRP78 Polyclonal Antibody
產(chǎn)品簡介：

Anti-GRP78 Polyclonal Antibody
應(yīng)用 WB IHC
稀釋比例WB 1:2000-5000.IHC 1:50-200.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號：K106525P

更新時間：2022-08-15

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產(chǎn)品介紹

Anti-GRP78 Polyclonal Antibody

英文名稱Anti-GRP78 Polyclonal Antibody
宿主Rabbit
別名BIP;GRP78;HEL-S-89n;MIF2
應(yīng)用WB IHC
稀釋比例WB 1:2000-5000.IHC 1:50-200.
交叉反應(yīng)Human Mouse Rat
蛋白分子量70kDa
Gene ID3309
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human GRP78
性狀液體
Public Immunogen RangeA synthetic peptide of human GRP78
Subcellular LocationsCytoplasm Endoplasmic reticulum lumen Melanosome
Swiss ProtP11021
克隆類型Polyclonal Antibody
背景資料The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

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